05 December 2025
Chronic oedema of the lower limb arises when the balance between capillary filtration, venous return, and lymphatic drainage is disrupted. Venous hypertension, most often resulting from venous reflux or obstruction, increases capillary pressure and fluid extravasation into the interstitial space (Eberhardt and Raffetto, 2014). Sustained oedema impairs oxygen and nutrient diffusion, promotes inflammation, and contributes to skin changes such as lipodermatosclerosis, hyperpigmentation, and ultimately ulceration (Moffatt et al, 2017). The development of venous leg ulcers is therefore closely linked to the chronic cycle of venous hypertension, oedema, and tissue breakdown, with healing often delayed by persistent swelling and recurrent episodes of cellulitis (Guest et al, 2020).