Each year, 245,000 people in the UK develop sepsis, with most cases arising in primary care (Rudd et al, 2020). Currently, around 20% of people who develop sepsis do not survive (Burki, 2018), and approximately 40% of survivors have cognitive or functional impairment (Prescott and Angus, 2018). In an effort to save lives and improve outcomes, the National Institute for Health and Care Excellence (NICE), in common with other international guidelines, has recommended that sepsis is treated within an hour with broadspectrum antibiotics (Academy of Medical Royal Colleges, 2022). On the 31 January 2024, NICE updated its NG51 guideline for the UK, which was originally published in 2016. The update includes recommendations on recognition and early assessment, initial treatment, escalating care, finding the source of infection, early monitoring, and information and support. This article updates readers on changes to the NICE guidance and how they affect clinical practice.