Moisture can affect the normal function and permeability of the skin, leaving our bodies susceptible to infection. The damaging effects of moisture-associated skin damage (MASD) impact a wide range of patient groups, however, wounds caused by moisture are often mistaken for and treated as if they are pressure ulcers. Moisture can come into contact with the skin from a number of sources, but damage can be treated in the same way, despite its cause. In the authors’ clinical opinion, if nursing staff are able to identify and treat skin damage correctly according to its aetiology, faster rates of healing, improved quality of life, and fewer resources used on wound care would be seen. This article looks at the identification of seven aetiologies of MASD following an audit, and the subsequent development and implementation of a protocol to improve and standardise skin care in the authors’ trust, which it was hoped would provide a dynamic and unified approach to the management and education of MASD.